Alterations in staining intensity for calcitonin gene-related peptide (CGRP) in osteoblasts of the periodontal ligament during orthodontic tooth movement

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Calcitonin Gene-Related Peptide (CGRP)

Calcitonin gene-related peptide (CGRP) is a 37 amino acid vasoactive neuropeptide that is widely distributed in central and peripheral nervous systems in mammals. CGRP was discovered in 1982 by molecular cloning of calcitonin (CT) gene. CGRP-specific mRNA appears to predominate in the hypothalamus while CT mRNA predominates in the thyroid. CGRP has an amphiphilic α-helical secondary structure i...

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The biomechanical behaviour of the hyalinized periodontal ligament in dogs during experimental orthodontic tooth movement.

During orthodontic tooth movement, the mechanical behaviour of the extracellular matrix of the periodontal ligament (PDL) determines the cellular processes involved in turnover of the PDL and alveolar bone. This mechanical behaviour is the basis for finite element (FE) models and FE analyses. Five young adult male beagle dogs were used to test the null hypothesis that the mechanical behaviour o...

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Analytical determination of stress patterns in the periodontal ligament during orthodontic tooth movement.

A dedicated software package that allows simulation of tooth movement can lead to shortening of the treatment program in orthodontics. A first step in the development of this software is the modelling of the movement of a single tooth. Forces applied to the crown of the tooth are transmitted to the alveolar bone through the periodontal ligament, stretching, and compressing the ligament, eventua...

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The effect of caffeine on orthodontic tooth movement in rats

Objective(s): to determine the effect of different doses of caffeine on orthodontic tooth movement (OTM) in rats. Materials and Methods: Forty male 250-300 g Sprague-Dawley rats were randomly divided into four groups of ten animals each and received 0 (control), 1 g/l, 2 g/l and 3 g/l caffeine in tap water for 3 days. Orthodontic appliances were ligated between the maxillary first molars and in...

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Periodontal parameters and cervical root resorption during orthodontic tooth movement.

OBJECTIVES To assess the relationship between periodontal parameters and cervical root resorption in orthodontically moved teeth. MATERIAL AND METHODS In a standardized experimental tooth movement in 16 periodontally healthy subjects, 29 pre-molars were tipped buccally for 8 weeks. Eighteen contralateral pre-molars not subjected to orthodontic movement served as controls. Plaque Index (PI), G...

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ژورنال

عنوان ژورنال: Biomedical Research

سال: 2004

ISSN: 0388-6107,1880-313X

DOI: 10.2220/biomedres.25.147